A Method to to Reduce the Effects of Nanoparticles on Healthy Cells
A research team from King Khalid University, led by Dr. Nasser Awad, Professor Ali Al-Shahrani, Dr. Kamel Tamimi, and Dr. Mohamed Hamdy, brilliantly devised a method to increase the effect of the natural product of the nanoparticle hydroxyapatite molecule on liver cancer cells by loading it onto the micro-magnesium oxide molecules.
The new mechanism adapts a vector that does not pose any risk while generating zero levels of cell toxicity. Moreover, it encapsulates and carries compounds known to have a weak effect on liver cancer cells. It is worth mentioning that nanoparticles may be dangerous if given to cells without encapsulation. Nanoparticles are known to have the ability to penetrate the cell membrane unhindered thereby increasing their risk to healthy cells.
The results showed that the carrier's ability to increase the efficiency of the molecules by more than thirty times although it carries half of the dose that has been identified in the cell culture laboratory known as IC50 in the University Biology Department, which is one of the leading laboratories in the region in particular and the Kingdom in general. This indicates the achievement of the previously sought targets, as wrapping these molecules contributes to reducing the risk of these molecules on healthy cells. This directly contributes to the reduction of doses, which will inevitably reduce the side effects.
Economically, the new discovery reduces the cost because it depends on the amount used as a treatment. The most significant challenge for the research team was to increase the ability of the carrier to specialize itself so that it can identify cancer cells from other healthy cells. Consequently, the carrier will be able to control cancer cells effectively while reducing the side effects to a negligible level. Collaboration between the research team members from the Molecular Biology and Chemistry Departments are still underway until they achieve this goal.
Limiting the Effects of Nanoparticles
The research team stressed that this research does not provide cancer treatment; however, it accurately presents researchers with a new way to reduce the effects of nanoparticles on healthy cells and reduce the doses to be used. The spokesperson of the team, Dr. Kamel Tamimi, said that the scientific community approved this development. The research was published in a high impact factor magazine classified as ISI Molecules. After the publication of the research, the number of researchers who utilized the research piece and requested permission conservatively reached 500 in just a matter of months. This indicates the relatively high level of importance of the idea and the global applications it holds.
The Scientific Research Deanship at King Khalid University cherishes scientific research in the university. And that is why the research team seized the opportunity and thanked the Rector for his unwavering support and encouragement to scientific research pursuits with international ambitions. The research team further thanked the Scientific Research Deanship headed by its Dean, Dr. Hamid Al-Qarni, who is following this development step by step.