A research team from the Faculty of Medicine at King Khalid University managed to diagnose and treat a severe pneumonia in a 4 year old child. X-rays that have been imaged to the patient showed he was suffering from severe pneumonia which was caused by a rare fungus. It was the first case to be found in Saudi Arabia, and in deed in the Middle East.
The medical team that diagnosed and treated the case included Dr. Martin Joseph, Dr. Ali Mohammed Sohail, Dr. Ahmed bin Mohammed Hakami, Dr. Mohamed Hamed - from the University Faculty of Medicine, as well as Dr. Ibrahim Zeid - from the Department of Pediatrics of Asir Central Hospital. The team managed to isolate and recognize rare fungus found in the specimens leak from the patient. X-ray result of the patient showed the presence of severe pneumonia with a blur in his right brow costal corner, and after examination and treatment, there was remarkable recovery of the patient's natural lung size.
The medical team has faced great difficulties in identifying the microbe through microscopic, virtual, and routine examinations, but thanks to the analysis of the DNA sequences in areas 1 and 2 (D1 / D2) of ribosomal DNA, and internal buffer zone (ITS) - private fungal were classified as the microbe with Tilletiopsis minor - which is rare and the second of its kind after one case in humans was discovered in the United States in 1997.
Due to the lack of the case's response to the antibacterial medications (vancomycin and Mirobenem), and after the diagnosis emphasized the existence of fungus, medications were replaced by the use of Amphotericin B. After that Voriconazole (liposomal) was added in the vein in order to control any onset of infection. The result was amazing when the patient recovered and left the hospital in good condition after a month.
The Dean of the Faculty of Medicine at King Khalid University Dr. Abdullah Asiri informed that the fungi belonged to "Telitiobss" which are dimorphic fungus and also classified in Exobasidiomycetes category which is characterized by the composition of blastoconidia, and without the formation of bud cells. The discovery of this fungus was in 1930 by a scientist called Dexter.
The team mentioned that the case that was displayed was serious and those pests and leaks in the chest were considered fatal, but thanks to God, the child had received the medication accurately and timely. The team also praised the wide horizon in the diagnosis and multiple possibilities, were important processes, and not easy one, needed the cooperation of medical teams and specialized laboratory analysis.
In recent years, the detection and diagnosis of Fungus in clinical samples as pathogens have increased due to the evolution in diagnostic techniques. High demand and the multiplicity of applications in the medical centers and academic institutions have led to the emergence of molecular analysis. In return, this has led to the emergence of, and development in, the important changes of fungus classification. Moreover, this has led to significant results such as the redefinition of many types of fungi and many other microbes, in addition to identifying new types as in the case of the fungi which was identified in this study. The study is being published in the Annals of Saudi Medicine.